Endocrine Abstracts

Maternally inherited diabetes and deafness (MIDD) is a rare form of diabetes caused by a mitochondrial DNA mutation. The condition is maternally inherited as mitochondrial DNA is practically only derived from oocytes. Patients typically have progressive insulinopenia, sensorineural hearing loss and maculardystrophy. We reported here 3 mitochondrial diabetes (two females and one male) and their families. Both of the 3 patients had diabetes, progressive loss of motor skills and ...

Backgrounds: Based on anthropometry and blood biochemical tests, this study aims to analyze the variation of glucose and lipid metabolism in Cushing’s syndrome (CS) patients caused by adrenal adenoma combining with flash glucose monitoring system (FGMS) and dual-energy X-ray absorptiometry (DEXA).Methods: According to the strict diagnostic and exclusion criteria, seven healthy controls (HCs) and seven CS patients were collected in this study. First,...

BackgroundsThe study aimed to explore the characteristics of glucolipid metabolism in patients with nonfunctional adrenal incidentaloma(NFAI). And investigate the relationship between these factors and insulin resistance, islet beta cell function.MethodsThis study enrolled eight patients with nonfunctional adrenal incidentaloma and five healthy controls(HCs). These data were recorded including body measuremen...

Introduction: As a tumor-suppressor gene, armadillo repeat-containing 5 (ARMC5) gene regulates steroidogenesis and cell apoptosis in manner of second-hit model. Mutations of ARMC5 gene will disturb its normal function, leading to reduced cortisol synthesis and cell apoptosis, which is acknowledged as a frequent cause of primary bilateral macronodular adrenal hyperplasia (PBMAH). Not until another somatic ARMC5 mutation occur in germline mutation carriers, will they manifest as...